M.Sc. in Biotechnology, Jawaharlal Nehru University, New Delhi
Ph.D. in Biochemistry from the Indian Institute of Science, Bangalore (2001)
Devyani Haldar obtained her M.Sc. in Biotechnology from Jawaharlal Nehru University (JNU), New Delhi and her Ph.D. degree in Biochemistry from the Indian Institute of Science, Bangalore. During her Ph.D., she worked with Prof. M.R.S. Rao, on purification of a structure-specific endonuclease from rat testis and demonstrated its function in processing intermediates of DNA metabolic processes such as DNA replication, repair and recombination. In 2002, she moved to the laboratory of Prof. Rohinton Kamakaka at the National Institutes of Health (NIH), USA as a post-doctoral fellow. There she worked on understanding the biological functions of the Sirtuin family of NAD-dependent protein deacetylases in model system fission yeast Schizosacharomyces pombe. She was involved in the discovery of the only known substrate of the fission yeast Sirtuin Hst4. Her work revealed that Sirtuin Hst4 deacetylates, Histone H3 lysine 56, a novel histone modification and deacetylation of this residue by Hst4 is required for DNA damage signaling pathway. In December 2006, Devyani joined the Institute of Life Sciences, Hyderabad where she had set up her independent research group and began to work on understanding functions of chromatin modifications in DNA metabolism, their role in maintenance of genomic integrity and implication in cancer progression. Her group also works on deciphering novel functions of Sirtuins in cell physiology. Her group is one of the first four research groups which simultaneously discovered acetylation of Histone H3 lysine 56 in mammalian cells and shown its function in DNA damage signaling. In March 2013, Devyani joined to CDFD as staff scientist and group leader, where she continues to pursue her study of epigenetic regulation of DNA metabolism and genomic integrity.